METHOD FOR OBTAINING PHARMACEUTICAL AGENT FOR INHIBITING PROLIFERATIVE ACTIVITY OF TUMOR CELLS Russian patent published in 2021 - IPC A61K33/26 A61P35/00 B82B3/00 B22F9/14 

FIELD: medicine.

SUBSTANCE: present invention relates to the field of medicine, namely to experimental research in oncology, and can be used to obtain a pharmaceutical agent for inhibiting the proliferative activity of cervical cancer cells Hela, including the use of a metal powder obtained by an electric explosion of a metal wire in a gas atmosphere, while an electric explosion of a low-carbon steel wire is conducted at a specific energy of 7-18 kJ/g and a pulse duration of 1.2-2 microseconds in the reactor previously evacuated to a residual pressure of 10^-2 Pa, and then filled with carbon monoxide to a pressure of 10⁵ Pa at a gas flow circulation rate in the reactor of 10 m/s, the explosion products deposited in the trap are passivated in the air atmosphere for at least 48 hours, the resulting powder is extracted and mixed with a solution of the RPMI-1640 nutrient medium with L-glutamine, whose pH is 7.2, in the proportion of the powder mass to the volume of the specified solution from 1:10 to 2.7:10, then centrifuged until the phases are separated, the liquid phase is drained and used as a pharmaceutical agent.

EFFECT: expansion of the arsenal of means for inhibiting the proliferative activity of tumor cells.

1 cl, 12 dwg, 3 ex