ANTIGEN-BINDING MOLECULE CAPABLE OF MULTIPLE BINDING OF TWO OR MORE ANTIGEN MOLECULES Russian patent published in 2021 - IPC C12N15/13 C12P21/08 C40B30/04 

Abstract RU 2756029 C2

FIELD: immunology.

SUBSTANCE: method for improving antibody pharmacokinetics is proposed, including substitution of at least one amino acid of a variable region of the specified antibody to histidine.

EFFECT: present invention can be further used in the production of antibodies with improved pharmacokinetic properties.

9 cl, 29 dwg, 17 tbl, 18 ex

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RU 2 756 029 C2

Authors

Igava Tomoyuki

Isii Sinya

Maeda Atsukhiko

Nakai Takasi

Dates

2021-09-24Published

2014-07-10Filed