FIELD: medicine; pharmaceutics.
SUBSTANCE: invention relates to heterocyclic compounds of the formula (I), where R1 and R2 are independently H, NH2 or C1-6 alkyl, or R1 and R2, together with two carbon atoms with which they are bound, are phenyl or heteroaryl selected from thienyl, imidazolyl and pyridyl; each of R3 and R4 is independently 
, or 
, which are such as disclosed in the claims; R5 is H; R6 is absent or is H; R7 is C3-10 cycloalkyl. The invention also relates to a pharmaceutical composition containing a compound of the formula (I), to a method for mobilizing hematopoietic stem cells (HSC) and endothelial progenitor cells (EPC) into peripheral blood circulation and to a method for treating hepatocellular carcinoma, renal damage, myocardial infarction, or mild traumatic brain injury.
EFFECT: technical result is compounds of the formula (I) used to disrupt the interaction between CXCR4 and CXCL12.
(I)
31 cl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| BROMDOMAIN INHIBITORS | 2012 |
|
RU2671571C1 |
| 1,3-DIOXOINDENE DERIVATIVES, THEREOF PHARMACEUTICALLY ACCEPTABLE SALT, METHOD OF OBTAINING THEREOF AND PHARMACEUTICAL ANTIVIRAL COMPOSITION, CONTAINING IT AS ACTIVE INGREDIENT | 2012 |
|
RU2566761C2 |
| LSD1 INHIBITOR, AS WELL AS ITS PRODUCTION METHOD AND ITS APPLICATION | 2018 |
|
RU2763898C2 |
| BROMDOMAIN INHIBITORS | 2012 |
|
RU2647592C2 |
| SUBSTITUTED TRICYCLIC COMPOUNDS AND METHOD OF APPLICATION | 2016 |
|
RU2744766C2 |
| DERIVATIVE CYCLIC AMINE AND ITS PHARMACEUTICAL APPLICATION | 2014 |
|
RU2638549C2 |
| MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | 2011 |
|
RU2576036C2 |
| BICYCLIC HETEROAROMATIC RING DERIVATIVE | 2019 |
|
RU2798838C2 |
| HYDROXYPURINE COMPOUNDS AND WAYS OF THEIR USE | 2015 |
|
RU2673458C1 |
| IMIDAZOPIRASOTHINES AS PDE1 INHIBITORS | 2016 |
|
RU2712219C2 |
