PHENYL [A]INDOLE [2,3-G] QUINOLYSINS, THEIR PREPARATION METHOD, COMPOSITIONS CONTAINING THEM AND APPLICATION OPTIONS Russian patent published in 2021 - IPC C07D471/14 C07D491/22 C07D495/22 A61K31/4725 A61P1/16 A61P3/04 A61P3/06 A61P9/10 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a condensed heterocyclic compound of the general formula (I) or its enantiomer, diastereomer, racemate and mixture thereof, where R₁ and R₂ are each independently selected from a group consisting of hydrogen, substituted or unsubstituted C1-C4 alkyl, substituted or unsubstituted C6-C10 aryl; and R₁ and R₂ are not both hydrogen or R₁ and R₂ and neighboring -(CH2)n-O and bound carbon atoms together form unsubstituted 5-element heterocyclic ring, wherein the specified heterocyclic ring is thiophene; each R₃, R₄ is independently selected from a group consisting of hydrogen, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C6-C10 aryl, substituted or unsubstituted 5-element heterocyclic ring, which is selected from thiophene, furan and pyrrole, unsubstituted benzyl, -SO₂R₉; R₅ is selected from a group consisting of hydrogen or halogen; R₆ and R₇ are each independently selected from a group consisting of hydrogen, unsubstituted C1-C2 alkyl, unsubstituted C1-C2 alkoxy, -OSO₂R₉; R₈ is hydrogen; R₉ and R₁₀ are independently hydrogen, unsubstituted C1-C6 alkyl or unsubstituted C6 cycloalkyl, C6-C10 aryl unsubstituted or substituted with 1 halogen, benzyl; wherein, if both of R₃ and R₄ are hydrogen, then at least one of R₁, R₂, R₆, R₇ is a group selected from a group consisting of substituted C6-C10 aryl; where “substituted” means that one, two or three hydrogen atoms in the group are substituted by a substituent selected from a group consisting of halogen, C1-C2 alkyl unsubstituted or substituted with three halogens, C1 alkoxy, hydroxy, cyano, unsubstituted 5-element heterocyclic ring selected from pyrazole, -NR₉R₁₀, -SO₂R₉, -OSO₂R₉, -COOR₉ and -OCOR₉; n is 1. The invention also relates to specific condensed heterocyclic compounds, a method for obtaining a compound of the formula (I) and a pharmaceutical composition based on a compound of the formula (I).

EFFECT: obtaining of a new condensed heterocyclic compounds useful for the treatment of metabolic diseases.

13 cl, 6 tbl, 414 ex