FIELD: pharmaceutics.
SUBSTANCE: invention relates to conjugates of peptide or peptidomimetic containing or consisting of a targeting sequence selected from a group consisting of SEQ ID NO: 24 and 25, wherein peptide or peptidomimetic is cyclic or has length of no more than 30 amino acids, and peptide or peptidomimetic is related to a component selected from a biologically active component and a diagnostic component. The conjugate is suitable for targeting a biologically active component or a diagnostic component to muscle cells. Such a biologically active or diagnostic component can be, for example, oligonucleotide, small interfering RNA, a gene, a virus, a protein, a drug, a small organic molecule, a pharmaceutical preparation or a detectable agent.
EFFECT: conjugate can be used, for example, to treat a muscle cell-related disorder.
20 cl, 17 dwg, 2 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| OLIGONUCLEOTIDE FOR TREATMENT OF PATIENTS WITH MUSCULAR DYSTROPHY | 2013 |
|
RU2789279C2 |
| OLIGONUCLEOTIDES SWITCHING OR MODULATING PRE-RNA SPLICING AND CONTAINING BICYCLIC FRAMEWORK FRAGMENTS WITH IMPROVED CHARACTERISTICS FOR TREATING GENETIC DISEASES | 2017 |
|
RU2769249C2 |
| MODIFIED OLIGONUCLEOTIDES AND METHODS OF THEIR USE | 2017 |
|
RU2802836C2 |
| BISPECIFIC ANTISENSE OLIGONUCLEOTIDES FOR DYSTROPHIN EXON SKIPPING | 2019 |
|
RU2819149C2 |
| DETERMINATION OF NUCLEIC ACIDS BY AMPLIFICATION BASED ON INCORPORATION INTO CHAIN | 2014 |
|
RU2694976C1 |
| COMPOSITIONS AND METHODS FOR INHIBITION OF PROTEOLYTIC PATH OF ARGININE/N-DEGRON | 2020 |
|
RU2787841C2 |
| SYSTEM FOR PRESENTATION OF PEPTIDES ON CELL SURFACE | 2016 |
|
RU2739593C2 |
| TOMATO PLANTS WITH IMPROVED TRAITS | 2019 |
|
RU2821992C2 |
| COMBINED PURIFICATION AND MEASUREMENT OF DNA METHYLATION WITH COMBINED MEASUREMENT OF MUTATIONS AND/OR LEVELS OF mRNA EXPRESSION IN AUTOMATED REACTION CARTRIDGE | 2017 |
|
RU2780660C2 |
| HSD17B13 OPTIONS AND THEIR APPLICATIONS | 2018 |
|
RU2760851C2 |
