NEW DERIVATIVES OF PHENYL PROPIONIC ACID AND THEIR APPLICATION Russian patent published in 2021 - IPC C07D405/12 C07D405/14 C07D409/12 C07D417/12 A61K31/443 A61K31/4433 A61K31/4436 A61K31/541 

FIELD: medicine.

SUBSTANCE: invention relates to a compound of the formula (I), its enantiomer, diastereomer or their pharmaceutically acceptable salts. In the formula (I), R¹ is hydrogen; R² is hydrogen or C_1-4 linear alkyl; R³ is selected from hydrogen, halogen, CN or OR⁸; R⁴ is hydrogen or OR⁸; R³ and R⁴ are not hydrogen at the same time; R⁸ is C_3-10 heterocycloalkyl containing 1-4 heteroatoms selected from N, O and S, or C_1-4 alkyl substituted with C_3-10 heterocycloalkyl containing 1-4 heteroatoms selected from a group of N, O and S; R⁵ and R⁶, each independently, is hydrogen, halogen, CN or C_1-4 linear alkoxy-group; Y is NH or O; Z₁ and Z₂, each independently, is CR⁷ or N: when Z₁ is N, Z₂ is CR⁷; and when Z₁ is CR⁷, Z₂ is N; W is CR⁷ or N; R⁷ is hydrogen or C_1-4 linear alkyl. The invention also relates to a pharmaceutical composition based on the compound of the formula (I), to a method for the treatment of a metabolic disorder, and to the use of the compound of the formula (I).

EFFECT: obtaining a compound of the formula (I) having GPR40 agonist properties.

(I)

11 cl, 1 tbl, 28 ex