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(19)

RU

(11)

2 760 359

(13)

C2

(51)

IPC

C07D403/14(2006-01-01)

A61K31/506(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2018112993, 2016-09-22

(24)

Start date

2016-09-22

(22)

Actual filing date

2016-09-22

(45)

Published

2021-11-24

(72)

Inventor

Astrand Annika Birgitta MargaretaGrimster Neil PatrickKawatkar SameerKettle Jason GrantNilsson Magnus K.Ruston Linette LysSu QibinVasbinder Melissa MarieWinter-Holt Jon JamesWu DedongYang WenzhanGrecu TudorMccabe JamesWoessner Richard DonaldChuaqui Claudio Edmundo

(73)

Holder

Dizal Pharmaceutical Co., Limited

COMPOUNDS AND METHODS FOR INHIBITING JAK Russian patent published in 2021 - IPC C07D403/14 A61K31/506 A61P35/00 

Abstract RU 2760359 C2

FIELD: medicine.

SUBSTANCE: invention relates to a compound of the formula (I), to its pharmaceutically acceptable salt or solvate, and to their solid forms, in which R1 is methyl or ethyl; R2 is selected from methyl, ethyl, methoxy and ethoxy; R3 is selected from hydrogen, chlorine, fluorine, bromine and methyl; R4 is selected from methyl, ethyl and -CH2OCH3; each of R5 and R6 is individually methyl or hydrogen; and R7 is selected from methyl, ethyl, -(СН2)2ОН and -(СН2)2OCH3. The invention also relates to a pharmaceutical composition for the treatment of JAK-related disorder based on the specified compounds.

EFFECT: new compounds and a pharmaceutical composition based on them are obtained, which can be used in medicine for the treatment of cancer.

28 cl, 32 dwg, 32 tbl, 73 ex

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RU 2 760 359 C2

Authors

Astrand Annika Birgitta Margareta

Grimster Neil Patrick

Kawatkar Sameer

Kettle Jason Grant

Nilsson Magnus K.

Ruston Linette Lys

Su Qibin

Vasbinder Melissa Marie

Winter-Holt Jon James

Wu Dedong

Yang Wenzhan

Grecu Tudor

Mccabe James

Woessner Richard Donald

Chuaqui Claudio Edmundo

Dates

2021-11-24—Published

2016-09-22—Filed

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