METHOD FOR THE QUANTITATIVE DETERMINATION OF DEXPANTHENOL AND CHITOSAN IN THEIR JOINT PRESENCE IN A GEL Russian patent published in 2021 - IPC G01N33/15 

FIELD: pharmaceutical chemistry.

SUBSTANCE: invention relates to pharmaceutical chemistry, namely the quantitative determination of dexpanthenol and chitosan when they are present together in a gel dosage form, which is necessary in the production of drugs based on these components, as well as their standardization and quality assessment during pharmaceutical analysis. The claimed method provides for the separation of dexpanthenol and chitosan by precipitating the latter with 1.0 Μ aqueous sodium hydroxide solution and determining its quantitative content by gravimetric method, followed by bringing the dexpanthenol solution to the volume of the supernatant and determining its content by high performance liquid chromatography with a UV detector on a steel column with a reversed phase (Waters, USA), using the method of constructing a calibration graph within the working concentrations.

EFFECT: ensuring the simplicity and versatility of the conditions for the quantitative determination of dexpanthenol and chitosan in their joint presence in pharmaceutical preparations in the form of a gel without the use of a multistage and narrowly targeted sample preparation process.

1 cl, 3 dwg, 1 ex