COMPOSITIONS AND METHODS FOR DEGRADATION OF IMPROPERLY PACKAGED PROTEINS Russian patent published in 2021 - IPC A61K38/21 A61P11/00 A61P25/28 G01N33/566 

Abstract RU 2761564 C2

FIELD: medicine.

SUBSTANCE: group of inventions relates to methods for enhancing degradation of improperly packaged proteins and protein aggregates. A composition for the treatment or prevention of a disease or disorder associated with an improperly packaged protein or protein aggregates contains a vector based on an adeno associated virus (AAV) containing a nucleic acid sequence encoding human TRIM11, where the specified disease or disorder is neurodegenerative disease or disorder. A method for the treatment or prevention of a disease or disorder associated with an improperly packaged protein or protein aggregates in a subject who needs it, a composition, and a method for the treatment or prevention of a disease or disorder associated with degradation of a functional mutant protein, where the specified disease or disorder is cystic fibrosis, and a method for obtaining a recombinant protein are also proposed.

EFFECT: enhancing degradation of improperly packaged proteins and protein aggregates.

9 cl, 42 dwg, 4 tbl, 5 ex

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RU 2 761 564 C2

Authors

Yan, Syaolu

Go, Lili

Dates

2021-12-10Published

2016-05-27Filed