DEUTERATED DEFACTINIB COMPOUNDS AND THEIR APPLICATION Russian patent published in 2021 - IPC C07D403/12 A61K31/506 A61P35/00 

Abstract RU 2761825 C1

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a compound of formula (I) or to its pharmaceutically acceptable salt, where each of R1-R3, R9, R10 and R13-R15 is independently selected from hydrogen or deuterium, and R4–R8, R11, R12 and R16-R18 are hydrogen. The invention also relates to a pharmaceutical composition for inhibiting FAK based on the specified compound of formula (I).

EFFECT: new compounds and a pharmaceutical composition based on them have been obtained that can be used in medicine to obtain anti-cancer drugs.

(I)

10 cl, 3 tbl, 4 ex

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RU 2 761 825 C1

Authors

Du, Vu

Li, Yu

Ven, Kun

Li, Sinkhaj

Chen, Yuanvej

Dates

2021-12-13Published

2019-05-06Filed