DEUTERATED DEFACTINIB COMPOUNDS AND THEIR APPLICATION Russian patent published in 2021 - IPC C07D403/12 A61K31/506 A61P35/00 

Abstract RU 2761825 C1

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a compound of formula (I) or to its pharmaceutically acceptable salt, where each of R1-R3, R9, R10 and R13-R15 is independently selected from hydrogen or deuterium, and R4–R8, R11, R12 and R16-R18 are hydrogen. The invention also relates to a pharmaceutical composition for inhibiting FAK based on the specified compound of formula (I).

EFFECT: new compounds and a pharmaceutical composition based on them have been obtained that can be used in medicine to obtain anti-cancer drugs.

(I)

10 cl, 3 tbl, 4 ex

Similar patents RU2761825C1

Title Year Author Number
FAK INHIBITOR AND DRUG COMBINATIONS THEREWITH 2019
  • Du, U
  • Li, Yu
  • Ven, Kun
  • Li, Sinkhaj
  • Chen, Yuanvej
RU2820555C2
HALOGEN-SUBSTITUTED PHENYLATE COMPOUND AND USE THEREOF 2020
  • Du, Vu
  • Li, Yuj
  • Li, Khajbo
  • Chen, Yuanvej
  • Chzhan, Chenchzhi
  • Li, Sinkhaj
RU2820475C2
PHTHALAZINE KETONE DERIVATIVE, METHOD OF OBTAINING THEREOF AND PHARMACEUTICAL APPLICATION 2011
  • Tan Pehn Cho
  • Li Sin'
  • Li Sjantsin'
  • Chehn' Jan
  • Van Bin'
  • Chzhu Chzhe
RU2564527C2
OBTAINING AND USING TRICYCLIC PYRIMIDINONE COMPOUND AND COMPOSITION THEREOF 2021
  • Gu, Chzhenkhua
  • Van, Duntsin
  • Khu, Yukhun
RU2820903C1
DERIVATIVE OF PYRIMIDINE AND A FIVE-MEMBERED NITROGEN-CONTAINING HETEROCYCLE, METHOD FOR PRODUCTION AND MEDICAL APPLICATIONS THEREOF 2019
  • Zou Hao
  • Li Zhengtao
  • Wang Yuanhao
  • Yu Jian
  • Zhu Wei
RU2775229C1
CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DESTRUCTION OF ANDROGEN RECEPTORS AND USE THEREOF 2020
  • Du, Vu
  • Ven, Kun
  • Fu, Ivej
  • Lv, Khajbin
  • Khe, Tszinyun
  • Tsin, Dekun
  • Li, Yuj
  • Duan, Tszini
  • Li, Yun
  • Aj, Chaovu
  • Tu, Chzhilin
  • Chen, Yuanvej
  • Li, Sinkhaj
  • Li, Khajbo
RU2825000C2
COMPOUNDS WITH SPIRO AND AROMATIC RINGS AND APPLICATION THEREOF 2019
  • Zheng, Qiangang
  • Xu, Ming
  • Zeng, Qinglong
  • Li, Jing
  • Zhuge, Hao
RU2781100C1
TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVE SALTS, METHODS FOR PREPARING THEM AND MEDICAL APPLICATION THEREOF 2010
  • Tan Pehn Cho
  • Sun' Pjaojan
  • Jan Fanlon
  • Ljan Tszin'Dun
  • Shehn' Guanjuan'
  • Van Jan
  • Fan' Tszjan
RU2523543C2
HETEROARYL[4,3-c]PYRIMIDINE-5-AMINE DERIVATIVE, ITS PREPARATION METHOD AND ITS MEDICAL APPLICATIONS 2018
  • Lu, Byao
  • Van, Shenlan
  • Shen, Syaodun
  • Khe, Fen
  • Tao, Vejkan
RU2764655C2
TRIAZOLO-PYRIMIDINE COMPOUNDS AND THEIR USE 2019
  • Tszen Tsinbej
  • Tsi Chankhe
  • Tsuj Khunchun
  • Yan Chzhenfan
  • Chzhan Syaolin
RU2802866C2

RU 2 761 825 C1

Authors

Du, Vu

Li, Yu

Ven, Kun

Li, Sinkhaj

Chen, Yuanvej

Dates

2021-12-13Published

2019-05-06Filed