FIELD: pharmaceutics.
SUBSTANCE: group of inventions relates to the pharmaceutical industry, namely to the treatment of cancer selected from bladder cancer, breast cancer, lung adenocarcinoma, pancreatic cancer or prostate cancer, with a composition derived from a whole Ambrosia maritime or Ambrosia hispida plant. A method for producing an extract containing sesquiterpene lactones for the treatment of bladder cancer, breast cancer, lung adenocarcinoma, pancreatic cancer or prostate cancer includes: a) processing of the whole Ambrosia maritime or Ambrosia hispida plant with a polar organic solvent, in which one or more sesquiterpene lactones are soluble; b) evaporation of the polar organic solvent to obtain an unrefined extract; c) processing of the unrefined extract by chromatography using chloroform to obtain a purified extract of the specified one or more sesquiterpene lactones; and d) collection of fractions of individual one or more sesquiterpene lactones. A composition for the treatment of cancer selected from bladder cancer, breast cancer, lung adenocarcinoma, pancreatic cancer or prostate cancer contains an organic extract of Ambrosia maritima or Ambrosia hispida obtained by the above-described method together with a pharmaceutically acceptable carrier. A method for the treatment of cancer selected from bladder cancer, breast cancer, lung adenocarcinoma, pancreatic cancer or prostate cancer includes administration to a patient suffering from cancer of the effective amount of the composition together with the pharmaceutically acceptable carrier. A method for the treatment of cancer selected from bladder cancer, breast cancer, lung adenocarcinoma, pancreatic cancer or prostate cancer includes the administration to a patient suffering from cancer of the effective amount of the composition containing sesquiterpene lactones extracted from Ambrosia hispida together with the pharmaceutically acceptable carrier. A method for reducing cancer metastasis includes the administration to a patient suffering from cancer of the effective amount of the composition containing sesquiterpene lactones extracted from Ambrosia maritima, while the specified cancer is bladder cancer, breast cancer, lung adenocarcinoma, pancreatic cancer or prostate cancer.
EFFECT: above-described group of inventions is effective for the treatment of cancer selected from bladder cancer, breast cancer, lung adenocarcinoma, pancreatic cancer or prostate cancer.
10 cl, 28 dwg, 4 tbl
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