PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF ACUTE MYELOID LEUKEMIA OR METASTATIC MAMMARY GLAND CANCER Russian patent published in 2021 - IPC C07D209/40 C07D401/14 C07D403/14 A61K31/403 A61K31/404 A61K31/496 A61P35/00 

Abstract RU 2763346 C2

FIELD: medicine.

SUBSTANCE: invention relates to a compound represented by the chemical formula 1 or its pharmaceutically acceptable salt, where R1 is hydrogen, R2 is fluor or C1-C4 alkyl composite ester, and R3 is structures (a), (b), (c) or (d). the invention also relates to a pharmaceutical composition for the prevention or treatment of a disease associated with the inhibition of FLT3 kinase containing (a) effective amount of the compound represented by the chemical formula 1 or its pharmaceutically acceptable salt; and (b) a pharmaceutically acceptable carrier.

EFFECT: obtaining compounds having inhibiting capability relatively to FLT3.

formula 1,

(а), (b), (c), (d)

5 cl, 4 tbl, 6 dwg, 5 ex

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RU 2 763 346 C2

Authors

Kim, En Chkhul

Chon, Pen Khva

Dates

2021-12-28Published

2018-10-30Filed