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(19)

(11)

2 766 146

(13)

(51)

IPC

C07C215/18(2006-01-01)

C07C215/28(2006-01-01)

C07C217/30(2006-01-01)

C07C217/32(2006-01-01)

C07C217/34(2006-01-01)

C07D205/04(2006-01-01)

C07D217/04(2006-01-01)

C07D311/88(2006-01-01)

A61K31/133(2006-01-01)

A61K31/135(2006-01-01)

A61P3/00(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2019113149, 2017-10-04

(24)

Start date

2017-10-04

(22)

Actual filing date

2017-10-04

(45)

Published

2022-02-08

(72)

Inventor

Chen, BeibeiMallampalli, Rama, K.Liu, Yuan

(73)

Holder

University Of Pittsburgh Of The Commonwealth System Of Higher EducationThe United States Government As Represented By The Department Of Veterans Affairs

AMPK LOW-MOLECULAR ACTIVATORS Russian patent published in 2022 - IPC C07C215/18 C07C215/28 C07C217/30 C07C217/32 C07C217/34 C07D205/04 C07D217/04 C07D311/88 A61K31/133 A61K31/135 A61P3/00 A61P29/00

Abstract RU 2766146 C2

FIELD: medicine.

SUBSTANCE: invention relates to compounds selected from a group consisting of compounds listed below or their pharmaceutically acceptable salts that prevent ubiquitinoylation and subsequent destruction of AMP-activated protein kinase (hereinafter – AMPK). The invention also relates to a method for the treatment of a disease or condition selected from sepsis, pneumonia, obesity and diabetes, a method for increasing the amount of phosphorylated AMPK in a cell, and a method for the violation of interaction between Fbxo48 protein and phosphorylated AMPK in a cell using the specified compounds.

EFFECT: obtaining compounds for the treatment of diseases.

, ,

7 cl, 1 tbl, 25 ex, 32 dwg

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RU 2 766 146 C2

Authors

Chen, Beibei

Mallampalli, Rama, K.

Liu, Yuan

Dates

2022-02-08—Published

2017-10-04—Filed