FIELD: medicine.
SUBSTANCE: invention relates to compounds selected from a group consisting of compounds listed below or their pharmaceutically acceptable salts that prevent ubiquitinoylation and subsequent destruction of AMP-activated protein kinase (hereinafter – AMPK). The invention also relates to a method for the treatment of a disease or condition selected from sepsis, pneumonia, obesity and diabetes, a method for increasing the amount of phosphorylated AMPK in a cell, and a method for the violation of interaction between Fbxo48 protein and phosphorylated AMPK in a cell using the specified compounds.
EFFECT: obtaining compounds for the treatment of diseases.
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7 cl, 1 tbl, 25 ex, 32 dwg
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