METHOD FOR PREDICTING ADVERSE CARDIOVASCULAR EVENTS WITHIN ONE YEAR AFTER A MYOCARDIAL INFARCTION BASED ON MOLECULAR GENETIC ANALYSIS Russian patent published in 2022 - IPC G01N33/50 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely cardiology, and can be used to predict adverse cardiovascular events within a year after a myocardial infarction on the basis of molecular genetic analysis. The method includes the determination of the following factors: the age of the patient at the time of myocardial infarction (MI), the presence in the genotype of the dominant allele D of I/D polymorphism of the ACE gene, the presence of a multivessel lesion of the coronary arteries (CA) involving the anterior descending artery (ADA) according to the results of coronary angiography (CAG) at the time of index MI, as well as the presence of coronary heart disease (CHD) in combination with arterial hypertension (AH) diagnosed before the development of index MI. The probability of the development of adverse cardiovascular events during the year after one suffered is calculated according to the following formula: p1/(1+EXP(-z)), where p is the probability of the development of adverse cardiovascular events; z is the value of the discriminant function. If the p value is equal to or more than 0.5, the development of adverse cardiovascular events is predicted within a year after suffering MI.

EFFECT: use of the invention makes it possible to determine with high accuracy the probability of the development of adverse cardiovascular events within a year after the previous MI, which contributes to the allocation of a priority cohort of patients with increased risk for subsequent more intensive dispensary monitoring and the organization of the most personalized measures aimed at preventing the development of adverse cardiovascular events in them in the post-infarction period.

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