SOFT GELATINOUS CAPSULES WITH HIGH STABILITY, CONTAINING HYDROXYPROPYL-BETA-CYCLODEXTRIN Russian patent published in 2022 - IPC A61K47/40 A61K31/196 A61K31/4985 A61K47/10 A61K9/48 

Abstract RU 2768630 C2

FIELD: pharmaceutics.

SUBSTANCE: group of inventions relates to a storage-stable soft gelatin capsule, a pharmaceutical composition containing such a capsule, method of its production and method of increasing stability of inner content and/or shell of such capsule. Soft gelatine capsule has an internal content with an active substance selected from diclofenac, diclofenac epolamine (DHEP), tadalafil or pharmaceutically acceptable salts thereof, and the shell of the said capsule contains hydroxypropyl-beta-cyclodextrin (HPBCD) in an amount of (a) less than 10% by weight of the shell weight and (b) a substoichiometric amount to form an inclusion complex with the active substance of the internal content.

EFFECT: disclosed gelatine capsules are stable during storage, prevent formation of by-products from the active substance and have high consistency of weight, id est low hygroscopicity.

13 cl, 2 tbl, 4 ex

Similar patents RU2768630C2

Title Year Author Number
STABLE INJECTABLE PARACETAMOL FORMULATION FOR INJECTIONS 2011
  • Tseti Julija
RU2519764C1
CAPSULES CONTAINING WATER FILLING COMPOSITIONS, STABILISED WITH DERIVATIVE OF CYCLODEXTRIN 2003
  • Tompson Dajan O.
  • Zimmerer Rupert O.
  • Pipkin Dzhejms D.
RU2359698C2
PHARMACEUTICAL COMPOSITION AND METHODS FOR USE 2017
  • Li, Yuhua
  • Huang, Chiating
  • Mao, John
RU2719450C1
METHOD FOR OBTAINING AMORPHOUS CO-EVAPORATES OF CLADRIBIN WITH CYCLODEXTRINS 2021
  • Babij Vladimir Evstakhievich
  • Konoplyannikov Ivan Georgievich
  • Zabudkin Oleksandr
  • Mata Vladimir
RU2758436C1
SUSTAINABLE STRUCTURES OF ANTITHROMBOCYTIC AGENTS, OMEGA-3 FATTY ACIDS AND AMYLOSE IN SOFT GELATIN CAPSULES 2012
  • Karuchchi Simone
  • Bernaredzhi Alberto
  • Markorri Mauritsio
  • Pontidzhia Marko
RU2630606C2
PHARMACEUTICAL SOFT GELATIN CAPSULE DOSAGE FORM WITH MODIFIED GUAR GUM 2014
  • Muldoon Brendan
  • Loughlin Ryan Gerald
  • Sweeney Gerarde
  • Boyd Emma Karen
RU2676480C2
METHOD OF OBTAINING A SOLID FORM OF THE DRUG SEDATIVE AND ANTISPASMODIC ACTION 2015
  • Aleksenko Pavel Vladimirovich
  • Titov Vladimir Vyacheslavovich
RU2578432C9
METHOD OF PREPARING THE COMPLEX OF SILIBININE WITH CYCLODEXTRIN, INCLUSION COMPLEX OF SILIBININE WITH CYCLODEXTRIN, PHARMACEUTICAL COMPOSITION SHOWING ANTIHEPATOTOXIC ACTIVITY AND A METHOD OF ITS PREPARING 1991
  • Umberto Valkavi[It]
  • Vintsentso Monterosso[It]
  • Roberto Kaponi[It]
  • Ehnriko Bozone[It]
  • Vil'Frid Peter Vakhter[De]
  • Jozhef Sejtli[Hu]
RU2108109C1
STABILISED AMORPHOUS FORMS OF IMANITIB MESYLATE 2008
  • Gonkalvesh Ehlizabete
  • Kal'B Oskar
  • Mutts Mikhaehl'
  • Virt Vol'Fgang
  • Lakshman Dzhej Partiban
RU2489149C2
PERORAL LIQUID COMPOSITIONS 2000
  • Uilson Ehdvard S.
  • Trespidi Laura A.
  • Klark Kristi M.
  • Desai Ashok Dzh.
  • Mejer Glenn A.
  • Sanchilio Frederik D.
RU2252019C2

RU 2 768 630 C2

Authors

Karuchchi, Simone

Markorri, Mauritsio

Pontidzha, Marko

Fossati, Titsiano

Dates

2022-03-24Published

2018-02-09Filed