CARRIER COMPOSITION FOR BONE REPLACEMENT MATERIALS Russian patent published in 2022 - IPC A61L27/02 A61L27/12 A61L27/18 A61L27/40 A61L27/46 A61L27/52 A61L27/58 A61F2/28 C08L71/02 B82B3/00 B82Y30/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to a carrier composition for dispersed and granular bone replacement materials. Carrier is a hydrogel containing: a block copolymer of ethylene oxide (EO) and propylene oxide (PO) or a mixture of block copolymers of ethylene oxide and propylene oxide (poloxamer 407, having an average molecular weight in range from 9,800 to 14,600 g/mol) and silicon dioxide nanoparticles having size of 0.5 to 10 nm, where the content of silicon dioxide nanoparticles is from 2 to 12 wt. %. Group of inventions also relates to a bone replacement material containing osteoconductive and/or osteoinductive particles or granules and the disclosed carrier composition. Also disclosed is a method of producing bone replacement material.

EFFECT: group of inventions provides obtaining thermally stable hydrogels which do not change into a liquid state even at low temperatures due to direct cross-linking of block copolymers with silicon dioxide nanoparticles.

16 cl, 16 dwg, 3 ex