METHOD FOR DIFFERENTIAL DIAGNOSIS OF ANEMIA SYNDROME IN TYPE 1 AND TYPE 2 DIABETES MELLITUS Russian patent published in 2022 - IPC G01N33/49 

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine, namely to clinical laboratory diagnostics. For the differential diagnosis of anemic syndrome in type 1 and type 2 diabetes, the parameters of iron metabolism are determined; in cases of a decrease of iron content in serum to less than 12.5 mmol/l in combination with the concentration of ferritin in the blood of ≥30 ng/ml in patients with diabetes mellitus, for the differential diagnosis of iron deficiency anemia (IDA) and anemia of chronic diseases (ACD), the following are additionally determined: ESR, the number of leukocytes, the level of microalbuminuria (MAU), the concentration of rTGF, the rTGF/log Ferritin index is calculated; with an increase in ESR≥26.5 mm/hour, an increase in the number of blood leukocytes ≥7.5×10⁹/l and an increase in MAU≥29.5 mg/l, ACD is diagnosed; with an increase in the concentration of rTGF≥1.42 ng/ml and the rTGF/log Ferritin index≥1.48, IDA is diagnosed; if the results of additional markers differ and data are obtained in favor of both ACD and IDA, anemia of complex genesis (IDA + ACD) is diagnosed.

EFFECT: method provides for effective and rapid differential diagnosis of the type of anemia syndrome (IDA and ACD) in patients with type 1 and type 2 diabetes mellitus, which ensures the correct choice of therapy.

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