FIELD: biotechnology.
SUBSTANCE: there are presented compositions and methods for preparing a live attenuated influenza vaccine suitable for nasal administration. This vaccine employs a cold-adapted influenza virus which does not contain a virulence factor, containing mutations providing the ability to replicate, sufficient for vaccine production.
EFFECT: vaccines obtained using said method provide significant cross-protection against strains not used for vaccination; said vaccine is safe for children under 2 years old and adults over 49 years old; besides, said cold-adapted virus with a deleted virulence factor can be adapted in order to obtain immunity from causative agents of diseases other than influenza.
9 cl, 12 dwg
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