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2 771 493

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IPC

C07K7/08(2006-01-01)

A61K38/10(2006-01-01)

A61P31/04(2006-01-01)

(21) (22)

Application

2021110763, 2021-04-15

(24)

Start date

2021-04-15

(22)

Actual filing date

2021-04-15

(45)

Published

2022-05-05

(72)

Inventor

Shamova Olga ValerevnaZharkova Mariya SergeevnaOrlov Dmitrij SergeevichKomlev Aleksej SergeevichVladimirova Elizaveta VasilevnaOvchinnikova Tatyana VladimirovnaPanteleev Pavel ValerevichBalandin Sergej VladimirovichKlimov Nikolaj Anatolevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Eksperimentalnoj Meditsiny"

PEPTIDE WITH ANTIBACTERIAL ACTIVITY AGAINST MICROORGANISMS WITH MULTIDRUG RESISTANCE Russian patent published in 2022 - IPC C07K7/08 A61K38/10 A61P31/04

Abstract RU 2771493 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biochemistry and can be used in medicine and veterinary medicine. Developed is a new RFR-ChBac3.4(1-14)-NH₂ antimicrobial peptide engineered by modifying (introducing deletions and inserts) the amino acid sequence of natural ChBac3.4 bactenecin.

EFFECT: synthetic RFR-ChBac3.4(1-14)-NH₂ peptide has a high antimicrobial activity against gram-positive and gram-negative bacteria, including multidrug-resistant bacteria, inhibits the growth of pathogenic bacteria synergistically with a number of antibiotics, and is also capable of preventing the formation of biofilms from pathogenic bacteria.

2 cl, 3 dwg, 6 tbl, 5 ex

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RU 2 771 493 C1

Authors

Shamova Olga Valerevna

Zharkova Mariya Sergeevna

Orlov Dmitrij Sergeevich

Komlev Aleksej Sergeevich

Vladimirova Elizaveta Vasilevna

Ovchinnikova Tatyana Vladimirovna

Panteleev Pavel Valerevich

Balandin Sergej Vladimirovich

Klimov Nikolaj Anatolevich

Dates

2022-05-05—Published

2021-04-15—Filed