FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular, to hybrid RNA (sgRNA) used as guide RNA in the Cas12d system for editing genomic DNA, as well as to a DNA cassette for expression thereof.
EFFECT: invention is effective for changing the sequence of genomic DNA of a unicellular or multicellular organism.
6 cl, 7 dwg, 2 tbl, 3 ex
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