POWDER SOLID DISPERSIONS INCLUDING QUERCETIN, METHOD FOR THEIR PRODUCTION AND THEIR COMPOSITIONS Russian patent published in 2022 - IPC A61K31/352 A61K47/24 A61K9/10 A61K9/14 A61K9/20 A61K9/48 

FIELD: powdered solid dispersion production.

SUBSTANCE: inventions group relates to a powdered solid dispersion containing quercetin, a method for its preparation, and a composition for oral administration containing the said solid dispersion. The proposed method for obtaining a powdery solid dispersion containing quercetin, phospholipids and a carrier that is readily-easily soluble in water and which is selected from the group consisting of mono- and disaccharides, polyalcohols, soluble oligo- and polysaccharides, includes dissolving or suspending in an anhydrous organic solvent and when heating quercetin, phospholipids and carrier, and then removing the solvent to obtain a powdery solid dispersion, where the method is carried out using solvents containing less than 5 wt.% water, and it does not include any steps of dissolution in water. Also provided is a powdered solid dispersion obtained by the above method, as well as an oral composition containing such a solid dispersion and one or more pharmaceutically acceptable and food acceptable excipients.

EFFECT: powdered solid dispersion obtained by the above process is characterized by improved solubility and oral bioavailability of quercetin in humans compared to quercetin per se.

19 cl, 1 dwg, 2 tbl, 8 ex