'FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, namely to an artificial nucleic acid molecule containing at least one open reading frame and at least one 3'-UTR element and optionally at least one 5'-UTR element, where the specified artificial nucleic acid molecule differs in a high translation efficiency compared to a translation efficiency of a reference nucleic acid molecule that is identical to the artificial nucleic acid molecule except for 3'-UTR element. The invention also relates to an expression vector, a cell for the production of polypeptide or peptide, pharmaceutical compositions for the vaccination or gene therapy, their use as a vaccine or gene therapy, a method for the production of an artificial molecule, a method for ensuring an increased translation efficiency, a vaccination kit, a gene therapy kit and the use of 3'-UTR element.
EFFECT: obtaining an artificial nucleic acid molecule.
31 cl, 9 dwg, 8 tbl, 3 ex
