NITROGEN-CONTAINING 6-ELEMENT CYCLIC COMPOUNDS Russian patent published in 2022 - IPC C07D417/14 C07D417/06 A61K31/549 A61P19/08 A61K31/5395 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a compound represented by the general formula (1), where R¹ is -H or halogen; Ar¹ is any substituent selected from a group G¹, which can be substituted with the same or different 1-3 substituents selected from a group consisting of -F and methyl (provided that structures represented by the formula 2 are excluded), in which the group G¹ is a group consisting of structures of the formula 3 (a and b are the direction of attachment); Ar² is any substituent selected from a group G², which can be substituted with the same or different 1-3 substituents selected from a group consisting of cyano, -Cl, methyl, methoxy and phenyl (provided that structures of the formula 4 are excluded), in which the group G² is a group consisting of phenyl, thienyl, furyl and thiazolyl; and * is asymmetric carbon, or its pharmaceutically acceptable salt. The invention also relates to a pharmaceutical composition having excellent agonistic activity relatively to EP₄ receptor, containing the effective amount of the compound according to the invention or its pharmaceutically acceptable salt, as an active ingredient, and a pharmaceutically acceptable carrier. The invention also relates to a pharmaceutical composition for the therapeutic treatment and/or stimulation of fracture healing, for stimulation of bone fusion during spinal surgery, containing the effective amount of the compound according to the invention or its pharmaceutically acceptable salt, as an active ingredient, and a pharmaceutically acceptable carrier.

EFFECT: compounds having excellent agonistic activity relatively to EP₄ receptor.

21 cl, 10 tbl, 39 ex