SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS AND THEIR USE FOR TREATMENT OF PATHOLOGICAL CONDITIONS Russian patent published in 2022 - IPC C07D487/04 C07D491/48 C07D495/04 C07D498/04 C07D513/04 A61K31/4365 A61K31/5025 A61P3/10 A61P13/12 A61P25/00 A61P27/06 

FIELD: medicine.

SUBSTANCE: invention relates to compounds of the formula I or its pharmaceutically acceptable salts that have a capability of activating glucocerebrosidase and can be used for the treatment of disorders, such as Gaucher disease, Parkinson’s disease and Lewy body disease. In the formula I, R^1A is C₁-C₆ alkyl, 3-10-element heterocyclil or 6-element aryl, where heterocyclil is a saturated, partially unsaturated or aromatic 3-10-element ring structure that includes from 1 to 4 heteroatoms, each of which is independently selected from nitrogen, oxygen and sulfur, and where heterocyclil and aryl are optionally substituted with 1, 2 or 3 substituents independently selected from a group consisting of halogen, C₁-C₆ alkyl, C₁-C₆ alkoxy and cyano; R^1B, in each case, is independently C₁-C₆ alkyl or halogen; R² is hydrogen; R³ is hydrogen; R⁴ is one of the following: C₃-C₈ cycloalkyl or partially unsaturated 9-10-element bicyclic carbocyclil, each of which optionally contains 1, 2 or 3 substituents independently selected from a group including C₁-C₈ alkyl, C₁-C₆ alkoxy group and C₂-C₄ alkynyl; or C_1-6 alkyl or C_2-6 alkynyl; Y is a bond, C₁-C₆ halogenalkylene or C₁-C₆ alkylene optionally substituted with C₃-C₆ cycloalkylene; and n is equal to 1. The invention also relates to different options of the specified compounds, a pharmaceutical composition including them, and a method for the treatment of a disorder selected from a group including Gaucher disease, Parkinson’s disease and Lewy body disease.

EFFECT: obtaining a compound for the treatment of Gaucher disease, Parkinson’s disease and Lewy body disease.

(I)

64 cl, 4 tbl, 3 ex