METHOD FOR ENHANCING TUMOR CELL DEATH IN COMBINATION OF IONIZING RADIATION AND CDK INHIBITOR Russian patent published in 2022 - IPC A61N5/10 A61K31/517 A61P35/00 

Abstract RU 2777869 C2

FIELD: medicine; oncology.

SUBSTANCE: invention relates to medicine, namely to oncology; it can be used for enhancing tumor cell death. A method includes impact with a drug 1 hour before radiation and radiation of bowel cancer cells with HCT116 dose of 4 Gr. An inhibitor of cyclin-dependent kinases CDK 8/19 Senexin B is used as the drug.

EFFECT: use of the invention allows for the reduction in survivability of tumor cells due to the action of a combination on their survival mechanism and prevention of the formation of resistance under the action of gamma-radiation.

2 cl, 2 ex, 3 dwg

Similar patents RU2777869C2

Title Year Author Number
COMPOSITION FOR PREVENTING CHEMORESISTANCE TO ANTIMITOTIC AGENTS 2022
  • Khamidullina Alvina Ilvirovna
  • Klimova Dariia Andreevna
  • Tatarskii Viktor Viacheslavovich
RU2807691C1
APPLICATION OF DNA FRAGMENT OF TRANSCRIBED REGION OF RIBOSOMAL REPEAT TO INCREASE STABILITY OF MESENCHIMAL STEM CELLS TO ACTION OF AGGRESSIVE ENVIRONMENTAL FACTORS 2013
  • Kostjuk Svetlana Viktorovna
  • Ershova Elizaveta Sergeevna
  • Smirnova Tat'Jana Dmitrievna
  • Kameneva Larisa Vladimirovna
  • Vejko Natal'Ja Nikolaevna
RU2560270C2
TREATING CANCER WITH COMBINATION OF RADIATION THERAPY, CERIUM OXIDE NANOPARTICLES AND CHEMOTHERAPEUTIC AGENT 2015
  • Baker, Cheryl
RU2704811C2
METHOD OF TUMOUR CELLS RADIOSENSITIZATION 2019
  • Gilyano Nadezhda Yakovlevna
  • Dubotolova Mariya Mikhajlovna
  • Ibatullin Farid Minikasimovich
RU2723393C1
METHOD FOR NON-CONTACT STIMULATION OF TRANSCRIPTIONAL ACTIVITY OF CYCLIN-DEPENDENT KINASE 2 INHIBITOR GENE IN PROSTATE TUMOR CELLS 2020
  • Kutilin Denis Sergeevich
  • Gusareva Marina Aleksandrovna
  • Zinkovich Mikhail Sergeevich
  • Maksimov Aleksej Yurevich
  • Shevchenko Aleksej Nikolaevich
  • Timoshkina Natalya Nikolaevna
  • Faenson Aleksandr Vladimirovich
  • Filatova Elena Valerevna
  • Pulatova Alina Aslankhanovna
RU2763992C1
SALTS OF 4-((2-(6-(4-METHYLPIPERAZINE-1-CARBONYL)-NAPHTHALEN-2-YL)ETHYL) AMINO)QUINAZOLINE-6-CARBONITRILE AND PHARMACEUTICAL COMPOSITION 2017
  • Aleshunin Pavel Aleksandrovich
  • Evstigneeva Elena Vladimirovna
  • Kopylova Olga Viktorovna
RU2641001C1
METHOD OF USING 4-((5,10-DIMETHYL-6-OXO-6,10-DIHYDRO-5H-PYRIMIDO[5,4-b]THIENO[3,2-e][1,4]DIAZEPIN-2-YL)AMINO)BENZENESULFONAMIDE (XMU-MP-1) TO INHIBIT GROWTH OF BURKITT'S LYMPHOMA CELLS 2023
  • Stepchenko Aleksandr Georgievich
  • Pankratova Elizaveta Vladimirovna
RU2814013C1
TREATING PANCREATIC CANCER AND NON-SMALL CELL LUNG CANCER WITH ATR INHIBITORS 2012
  • Pollard Dzhon Robert
  • Riper Filip Majkl
RU2648507C2
BRAF KINASE INHIBITOR N-(3-(5-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-3-CARBONIL)-2,4-DIFLUOROPHENYL)PROPANE-1-SULFONAMIDE 2018
  • Leonov Sergej Viktorovich
  • Chuprov-Netochin Roman Nikolaevich
  • Ivanenkov Yan Andreevich
RU2687107C1
CANCER TREATMENT WITH TG02 2017
  • Estok, Thomas M.
  • Weber, Eckard
  • Parrott, Tracy
RU2749025C2

RU 2 777 869 C2

Authors

Kuchur Oleg Aleksandrovich

Zavirskij Aleksandr Vladimirovich

Basharin Vadim Aleksandrovich

Dukhinova Marina Sergeevna

Shtil Aleksandr Albertovich

Dates

2022-08-11Published

2020-09-23Filed