FIELD: medicine.
SUBSTANCE: invention relates to the field of molecular biology, molecular genetics and cell biology, in particular to the application of a DNA-construction for inducing an expressed adaptive effect in mesenchimal stem cells. The said genetic construction includes CpG- and a GC-rich insert of a transcribed region of the human ribosomal repeat (region from -515 to 5321 (HSU13369, GeneBank)) and vector pBR322 in low concentrations (10-50 ng/ml).
EFFECT: invention makes it possible to increase the stability of MSC to the action of aggressive factors.
4 dwg, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| RECOMBINANT PLASMID pCpG-CytDA/upp FOR EXPRESSION OF FUSION PROTEIN CYTOSINE DEAMINASE-URASILPHOSPHORIBOSYL TRANSFERASE, RECOMBINANT PLASMID pCpG-CytDA/upp/VP22 FOR EXPRESSION OF FUSION PROTEIN CYTOSINE DEAMINASE-URASILPHOSPHORIBOSYL TRANSFERASE-VP22, THERAPEUTIC COMPOSITION FOR THERAPY OF CANCEROUS DISEASES AND METHOD FOR USE THEREOF | 2012 |
|
RU2580220C2 |
| STEM CELL PREPARATION WITH REPROGRAMMED CELL SIGNALLING, METHOD FOR MAKING THIS PREPARATION AND APPLICATION THEREOF | 2008 |
|
RU2428475C2 |
| METHOD FOR INCREASING THE PROLIFERATIVE POTENTIAL OF THREE-DIMENSIONAL TUMOR CELL CULTURES | 2021 |
|
RU2782600C1 |
| METHOD OF ESTIMATING ANGIOGENIC POTENTIAL OF PROGENOTOR CELLS IN PATIENTS WITH CARDIOVASCULAR DISEASES | 2011 |
|
RU2548801C2 |
| USING MESENCHYMAL AND NEURONAL MARKER EXPRESSING STEM CELLS AND THEIR COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASES (VERSIONS) | 2017 |
|
RU2742828C2 |
| STEM CELLS EXPRESSING MESENCHYMAL AND NEURONAL MARKERS, COMPOSITIONS THEREOF AND METHODS OF PRODUCING SAID MESENCHYMAL AND NEURONAL MARKERS | 2017 |
|
RU2741839C2 |
| COMPOSITION FOR AMPLIFICATION OF TRANSGENE EXPRESSION IN EUCARIOTIC CELLS, AND METHOD FOR INCREASING GENERATION OF TARGET PROTEIN CODED WITH TRANSGENE | 2013 |
|
RU2546249C2 |
| METHOD FOR CARDIO-GENERATIVE POTENTIAL DETERMINATION IN MAMMAL CELLS | 2010 |
|
RU2624498C2 |
| METHOD FOR PRODUCING ASSOCIATES OF HEMATOPOIETIC AND STROMAL PROGENITOR CELLS CAPABLE OF SUPPRESSING ACTIVATION AND PROLIFERATION OF ALLOGENIC LYMPHOCYTES | 2019 |
|
RU2722669C1 |
| GENETIC CASSETTE CONTAINING CODON-OPTIMIZED NUCLEOTIDE SEQUENCES OF TRAIL, PTEN AND IFNβ-1 GENES, AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ONCOLOGIC DISEASES | 2020 |
|
RU2757502C1 |
