FIELD: cardiology, oncology and rehabilitation.
SUBSTANCE: it can be used to predict the progression of chronic heart failure (CHF) in patients with breast cancer after anthracycline chemotherapy. DNA is isolated from the buccal epithelium by phenol-chloroform extraction. The alleles are typed and the 1772C>T (rs11549465) polymorphic locus of the hypoxia-induced factor 1 alpha gene is determined. If carriers of the C/T genotype have a high risk of progression of CHF during 24 months of observation, a high risk is predicted.
EFFECT: method allows to select a priority group of patients for dispensary observation with the organization of effective targeted measures aimed at preventing the progression of CHF and preventing high premature mortality by identifying the C/T genotype of the 1772C>T (rs11549465) polymorphic locus of the hypoxia-induced factor 1 alpha gene in patients with breast cancer after anthracycline chemotherapy.
1 cl, 4 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PERSONALIZED SELECTION OF PATIENTS WITH ANTHRACYCLINE-INDUCED CARDIOMYOPATHY AFTER POLYCHEMOTHERAPY OF BREAST CANCER FOR EFFECTIVE TREATMENT WITH CARVEDILOL | 2021 |
|
RU2778612C1 |
| METHOD FOR PREDICTION OF ANTHRACYCLINE-INDUCED CARDIOTOXICITY IN WOMEN WITH BREAST CANCER | 2019 |
|
RU2714683C1 |
| METHOD FOR PREDICTING PROGRESSION OF ANTHRACYCLINE-INDUCED CHRONIC HEART FAILURE IN PATIENTS WITH BREAST CANCER WITHIN 24 MONTHS | 2022 |
|
RU2793672C1 |
| METHOD FOR PREDICTING DEVELOPMENT OF CARDIOTOXICITY IN PATIENTS WITH BREAST CANCER WITHIN 12 MONTHS AFTER CHEMOTHERAPY WITH ANTRACYCLIC DRUGS | 2018 |
|
RU2680139C1 |
| METHOD FOR PREDICTING CLINICAL COURSE OF CHRONIC CARDIAC FAILURE IN PATIENTS WITH ISCHEMIC HEART DISEASE | 2014 |
|
RU2545899C1 |
| METHOD FOR PREDICTION OF SUBACUTE ANTHRACYCLINE-MEDIATED CARDIOTOXICITY DEVELOPMENT IN ONCOLOGICAL PATIENTS | 2020 |
|
RU2744682C1 |
| METHOD OF DIFFERENTIAL PRESCRIPTION OF β-ADRENORECEPTOR BLOCKING AGENTS IN PATIENTS WITH CHRONIC CARDIAC FAILURE | 2010 |
|
RU2454998C1 |
| METHOD FOR PREDICTION OF ATRIAL FIBRILLATION DEVELOPMENT IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME | 2022 |
|
RU2793677C1 |
| METHOD FOR PREDICTING THE PROGRESSION OF HEART FAILURE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME | 2022 |
|
RU2796311C1 |
| METHOD FOR PREDICTING THE DEVELOPMENT OF VARIOUS DEGREES OF SEVERITY OF CHRONIC HEART FAILURE | 2021 |
|
RU2772359C1 |
