TITANIUM IMPLANT WITH A SURFACE MODIFIED TO ENHANCE CELL ADHESION AND THE METHOD FOR ITS MANUFACTURE Russian patent published in 2022 - IPC A61F2/00 A61D1/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine and veterinary medicine and can be used in osteo-reconstruction to replace defects in bone tissue destroyed due to the development of a tumor. As the basis of the implant, a billet made of Ti-4%Fe alloy is used by a method characterized by the presence of an ω-phase, melted in a vacuum levitation unit and sawn using electro-erosion cutting. Then the surface of the workpiece is sanded using a series of sanding papers with a consistently decreasing grain size on a rotating disk. Then the microrelief is applied by unidirectional grinding without rotation using abrasive paper No. 2000 with an abrasive grain size of 10 microns. The resulting implant is characterized by microhardness, density and Young’s modulus, effective for replacing bone defects due to the manufacture of Ti-4%Fe alloy.

EFFECT: due to the modification of the surface in the form of a microrelief, represented by parallel furrows with a depth of 10±2 microns, the implant is able to selectively stimulate the adhesion of cells with osteogenic potential of 13±3 microns in suspension and colonization of the implant surface by them, inhibiting the adhesion of microorganisms with a size of 2±1 microns, which in the future mediates neo-osteogenesis and accelerated osseointegration after implantation.

2 cl, 3 ex, 3 dwg