RECOMBINANT NON-PATHOGENIC STRUCTURES OF MAREK'S DISEASE VIRUS, ENCODING SET OF HETEROLOGOUS ANTIGENS Russian patent published in 2022 - IPC C12N7/00 C12N15/86 C12N15/869 A61K39/00 A61K39/12 

FIELD: biotechnology.

SUBSTANCE: group of inventions is described, including a recombinant non-pathogenic Marek’s disease virus (hereinafter – rMDV_np) for protection of hens from a virus selected from a group consisting of Newcastle disease virus (hereinafter – NDV), infectious laryngotracheitis virus (hereinafter – ILTV), infectious bursitis virus (hereinafter – IBDV), Marek’s disease virus (hereinafter – MDV), and any combination thereof, an immunogenic composition containing rMDV_np, a vaccine containing the immunogenic composition, and a method for protection of chickens from a virus, including the administration of the vaccine. In one implementation, rMDV_np contains at least three heterologous nucleotide sequences located in an insignificant genome site of rMDV_np.

EFFECT: invention expands the arsenal of means for protection of chickens from a virus selected from a group consisting of NDV, ILTV, IBDV, MDV, and any combination thereof.

16 cl, 5 dwg, 9 tbl, 7 ex