CONSTRUCTS OF RECOMBINANT NONPATHOGENIC MAREK'S DISEASE VIRUS CODING ANTIGENS OF INFECTIOUS LARYNGOTRACHEITIS VIRUS AND NEWCASTLE DISEASE VIRUS Russian patent published in 2017 - IPC C12N15/86 C12N7/01 C12N15/869 A61K39/245 

FIELD: biotechnology.

SUBSTANCE: inventions relate to recombinant nonpathogenic Marek's disease virus (rMDV_np) representing a recombinant herpesvirus of turkeys (rHVT) and to the vaccine containing such virus and to the way of protecting hens from infectious laryngotracheitis virus (ILTV) and Newcastle disease virus (NDV). The presented virus contains the first nucleic acid inserted in the first unnecessary region of rMDV_np genome and the second nucleic acid inserted in the second unnecessary region of rMDVnp genome. The first nucleic acid comprises of a nucleotide sequence coding gD and gI ILTV proteins. The second nucleic acid contains a nucleotide sequence coding a Newcastle disease virus fusion protein (NDV F). The first unnecessary region and the second unnecessary region either are one and the same unnecessary region, or the first unnecessary region is a US2 region and the second unnecessary region is a UL7/8 region.

EFFECT: inventions allow for obtaining a stable means of protection from ILTV and NDV.

10 cl, 2 dwg, 5 tbl, 6 ex