Show metadata Hide metadata

(19)

(11)

2 782 194

(13)

(51)

IPC

C07D241/12(2006-01-01)

A61K31/4965(2006-01-01)

A61P7/02(2006-01-01)

(21) (22)

Application

2021127043, 2021-09-13

(24)

Start date

2021-09-13

(22)

Actual filing date

2021-09-13

(45)

Published

2022-10-24

(72)

Inventor

Dzhemilev Usein MemetovichShajbakova Mariya GennadevnaKhafizova Lejla OsmanovnaRamazanov Ilfir RifovichRikhter Nikita Andreevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Ufimskij Federalnyj Issledovatelskij Tsentr Rossijskoj Akademii Nauk

METHOD FOR PREPARATION OF 2,3,5,6-TETRAALKYLPYRAZINES Russian patent published in 2022 - IPC C07D241/12 A61K31/4965 A61P7/02

Abstract RU 2782194 C1

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a method for preparing 2,3,5,6-tetraalkylpyrazines of interest as antiplatelet and antihyperglycemic drugs, estrogen receptor regulators, as well as important compounds for diagnostic medicine.

EFFECT: new method has been developed for the production of 2,3,5,6-tetraalkylpyrazines, which consists in the interaction of nitriles of the general formula R-C≡N with EtAlCl₂ in the presence of magnesium (Mg, powder) and the catalyst Cp₂TiCl₂ at 60-65°C and atmospheric pressure for 12-18 hours, while the yield of 2,3,5,6-tetraalkylpyrazines is 60-91%.

1 cl, 1 tbl, 1 ex

Similar patents RU2782194C1

Title	Year	Author	Number
PRODUCTION PROCESS OF 2,3,5,6-TETRAFENYL(BENZYL)PYRASINE	2017	Khafizova Lejla Osmanovna Shajbakova Mariya Gennadevna Rikhter Nikita Andreevich Tyumkina Tatyana Viktorovna Dzhemilev Usein Memetovich	RU2672470C1
METHOD OF OBTAINING TETRAALKYL-SUBSTITUTED FURANS	2012	Dzhemilev Usein Memetovich Khafizova Lejla Osmanovna Shajbakova Marija Gennad'Evna Tjumkina Tat'Jana Viktorovna	RU2536407C2
PROCESS FOR THE PREPARATION OF 3-ALKYL(PHENYL)-2,5-DIPHENYL-1H-PYRROLES	2017	Khafizova Lejla Osmanovna Shajbakova Mariya Gennadevna Rikhter Nikita Andreevich Tyumkina Tatyana Viktorovna Dzhemilev Usein Memetovich	RU2677470C2
METHOD FOR METHYL n-[3,4-DIALKYL-5-(n-METHOXY-n-OXOALKYL)-2-FURYL] ALKANOATES PRODUCTION	2015	Khafizova Lejla Osmanovna Shajbakova Mariya Gennadevna Chobanov Nuri Mamedeevich Dzhemilev Usein Memetovich	RU2614250C2
METHOD FOR PREPARING 1-CHLORO-2,3,4,5-TETRAALKYLALUMINACYCLOPENTA-2,4-DIENES	2005	Dzhemilev Usein Memetovich Ibragimov Askhat Gabdrakhmanovich Khafizova Lejla Osmanovna Jakupova Lilija Rafikovna Popod'Ko Natal'Ja Romanovna Kovtunenko Irina Anatol'Evna	RU2283315C1
2,3-DIALKYL-2-CYCLOOCTENE-1-ONE PREPARATION PROCESS	2016	Khafizova Lejla Osmanovna Shajbakova Mariya Gennadevna Chobanov Nuri Mamedeevich Dzhemilev Usein Memetovich	RU2664661C2
METHOD FOR OBTAINING 2,5-BIS(2-METHOXYETHYL)-3-ALKYL(PHENYL)-1H-PYRROLES	2021	Dzhemilev Usein Memetovich Shajbakova Mariya Gennadevna Khafizova Lejla Osmanovna Ramazanov Ilfir Rifovich Rikhter Nikita Andreevich	RU2771232C1
METHOD OF PRODUCING DICYCLOALKYL(BICYCLO[2.2.1]HEPT-2-YL)ALKYLBORONATES	2019	Khafizova Lejla Osmanovna Khusainova Liliya Inverovna Ryazanov Kirill Sergeevich Tyumkina Tatyana Viktorovna Dzhemilev Usein Memetovich	RU2710586C1
METHOD OF PRODUCING 2,3-DIALKYL-1,4-DICYCLOPROPYL-1,4-BUTANEDIONES	2014	Khafizova Lejla Osmanovna Shajbakova Marija Gennad'Evna Tjumkina Tat'Jana Viktorovna Chobanov Nuri Mamedeevich Dzhemilev Usein Memetovich	RU2565789C1
METHOD OF JOINT RECOVERY OF 2,3-DIALKYL-2-CYCLOHEPTENE-1-ONES AND 2,3-DIALKYL-2-CYCLOHEPTENE-1,4-DIONES	2015	Khafizova Lejla Osmanovna Shajbakova Mariya Gennadevna Chobanov Nuri Mamedeevich Dzhemilev Usein Memetovich Tyumkina Tatyana Viktorovna	RU2624904C2

RU 2 782 194 C1

Authors

Dzhemilev Usein Memetovich

Shajbakova Mariya Gennadevna

Khafizova Lejla Osmanovna

Ramazanov Ilfir Rifovich

Rikhter Nikita Andreevich

Dates

2022-10-24—Published

2021-09-13—Filed