FIELD: medicine.
SUBSTANCE: present invention relates to a pharmaceutical composition containing an aqueous suspension of: (i) crystal N-(3,4-dichlorphenyl)-3-(pyridine-4-yl)-7-oxabicyclo[2.2.1]heptane-2-carboxamide or its pharmaceutically acceptable salt; and (ii) a surfactant containing water-soluble copolymer characterized by water solubility of > 5% at 25°C.
EFFECT: compositions provide prolonged release of N-(3,4-dichlorphenyl)-3-(pyridine-4-yl)-7-oxabicyclo[2.2.1]heptane-2-carboxamide, and they are suitable for intra-articular injection to the articulation of a patient suffering from arthritis, articulation injury, or cartilage injury.
17 cl, 3 dwg, 9 tbl, 11 ex
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