TETRASUBSTITUTED IMIDAZOLE DERIVATIVES AS CANNABINOID CB RECEPTOR MODULATORS, HIGHLY SELECTIVE TO SUBRANGE RECEPTORS CB/CB Russian patent published in 2009 - IPC C07D233/90 A61K31/4164 A61K31/4166 A61P5/00 A61P11/06 A61P25/00 A61P25/16 A61P25/28 A61P1/00 A61P15/00

Abstract RU 2354650 C2

FIELD: chemistry.

SUBSTANCE: invention refers to 1,2,4,5-tetrasubstituted imidazole derivatives of general formula (I) , where R₁ represents chlorine, bromine, fluorine or hydrogen atom, R₂ represents chlorine or bromine atom, A represents nitrogen atom or group CH, X represents sulphur atom or sulphoxide (S=O) group, or sulphonic (SO₂) group, Y represents hydrogen atom or methyl, ethyl, n-propyl, isopropyl, n-butyl, tert-butyl group, Z represents CH group, n represents number 1,2 or 3, and pharmacologically acceptable salts of compounds. Besides, the invention concerns a pharmaceutical composition based on the compound of general formula (I), to the compounds of general formulas and and to application of compounds of general formula (I).

EFFECT: new imidazole derivatives being selective modulators of cannabinoid receptors CB₁ with high selectivity.

12 cl, 1 tbl, 4 ex

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RU 2 354 650 C2

Authors

Lange Jozefus Kh.M.

Vals Khenderik K.

Kruse Kornelis G.

Dates

2009-05-10—Published

2005-05-26—Filed