MATERIALS AND METHODS FOR CANCER TREATMENT Russian patent published in 2023 - IPC C12N5/783 C12N9/22 C07K14/535 A61K35/17 A61P35/00

Abstract RU 2787828 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, in particular to a method for the production of T-cell with a chimeric antigen receptor, having a decreased level of polypeptides of a granulocyte-macrophage colony-stimulating factor (GM-CSF). A method for improvement of T-cell effector functions of T-cell with a chimeric antigen receptor is also disclosed.

EFFECT: invention is effective for the treatment of a mammal suffering from cancer.

17 cl, 21 dwg, 1 tbl, 6 ex

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RU 2 787 828 C2

Authors

Kenderian, Saad J.

Sterner, Rosalie M.

Cox, Michelle J.

Sakemura, Reona

Dates

2023-01-12—Published

2019-05-31—Filed