METHOD FOR COMBINED TREATMENT OF NON-MUSCLE-INVASIVE BLADDER CANCER T1-T2 N0+M0 Russian patent published in 2023 - IPC A61N5/06 A61B17/00 A61K31/409 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to oncology and urology. Fluorescent diagnostics and marking of tumor fluorescence boundaries and occult cancer foci are carried out, photodynamic therapy (PDT) session and subsequent transurethral resection (TUR) are carried out, while the photosensitizer Photoditazine is injected intravenously 2 hours before the PDT session at a rate of 0.75 mg per 1 kg body weight, while the analysis of the accumulation of the photosensitizer in the tumor and the determination of its boundaries are performed using the LESA-01 BIOSPEC laser electron spectral device, then a PDT session is performed using laser radiation with a wavelength of 662 nm and a power of 1.3 W, with a total energy used is 200 J, after that, the effect of photobleaching is studied using a LESA-01 BIOSPEC laser electron spectral device, the measurement is carried out in 1 mm increments from the center to the borders of the tumor at four points, then TUR of a visible tumor of the bladder mucosa is performed, as well as delivery of laser light to the tumor tissue is carried out using flexible mono fiber end light guides with a cylindrical diffuser during video cystoscopy through the working channel of the apparatus.

EFFECT: method makes it possible to increase the effectiveness of the method for treating bladder cancer and its relapses by reducing tissue trauma and shortening the healing time, reducing the number of relapses and improving the quality of life of patients.

1 cl, 2 ex