METHOD FOR ASSESSING THE RISK OF COMPLICATIONS OF THE INFECTIOUS PROCESS IN PATIENTS WITH CYSISTIC FISSIDOSIS Russian patent published in 2023 - IPC G01N33/50 A61B5/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to clinical laboratory diagnostics, microbiology, pulmonology, and can be used to assess the risk of developing complications of an infectious process in patients with cystic fibrosis. The method is implemented in that, in contrast to the known methods for assessing the risk of complications of an infectious process in patients with cystic fibrosis, sputum from patients with cystic fibrosis is collected in a sterile disposable container, centrifuged at 1700 G for 5 minutes, the resulting supernatant is re-centrifuged at 4500 G for 5 minutes. within 5 minutes. After that, the concentration of ferritin is determined on an automatic biochemical analyzer using the immunoturbodimetric method, characterized in that the study is carried out in dynamics with the calculation of the PCV coefficient: if the patient is not exacerbated, then the PCV coefficient is calculated between two consecutive determinations of ferritin in sputum with an interval of 1 time per 3 months, with a PCV value <37.3%, the risk of an exacerbation of the infectious process is low; during an exacerbation, the PCV coefficient is calculated between the last ferritin value determined outside the exacerbation and the ferritin value determined during the exacerbation, a PCV value from 37.3% to 45.7% inclusive corresponds to an exacerbation without seeding microorganisms from the Burkholderia cepacia complex; a value from 45.8% to 78.3% inclusive corresponds to an exacerbation with the inoculation of microorganisms from the Burkholderia cepacia complex; an increase in the PCV value above 78.4% corresponds to the "cepation syndrome".

EFFECT: invention provides an assessment of the risk of complications of the infectious process in patients with cystic fibrosis according to the Personal Change Value (PCV) coefficient for ferritin in sputum.

1 cl, 2 dwg, 4 ex