LOW-VOLUME METHOD FOR EXTRACORPOREAL PHOTOCHEMOTHERAPY Russian patent published in 2023 - IPC A61N5/06 A61M1/36 A61P37/06 

FIELD: medicine.

SUBSTANCE: invention relates to medicine; it can be used for the treatment of diseases and pathological conditions in adults and children, requiring modification of an immune response and immune tolerance. First, 20-30 ml of patient’s whole blood is exfused to a reservoir with anticoagulant; the resulting whole blood is introduced into a container for irradiation, and a cell product is prepared by addition of a sterile 0.9% sodium chloride solution until indicators of a cell product satisfying irradiation requirements are reached: a volume of at least 100 ml, but no more than 300 ml, hematocrit of no more than 3%; then, a photosensitizer is introduced in terms of 0.20-0.22 mg of psoralene per 1 ml of the cell product, and the cell product is irradiated with ultraviolet of the range A on MacoGenic G2 device (Macopharma, France), at a dose of 2 J/cm²; after that, the treated product is intravenously injected in drops to the patient.

EFFECT: invention provides achievement of a therapeutic effect of photochemotherapy in the form of modification of an immune response in the treatment of diseases and pathological conditions of adults and children, without hardware leukapheresis.

1 cl, 1 tbl, 2 ex