FIELD: experimental medicine.
SUBSTANCE: invention relates to experimental medicine, in particular to cholera prophylaxis method using drugs based on vesicles of outer membrane virulent strains of Vibrio cholerae O1 El Tor and Vibrio cholerae O139. Mice of 16-20 g mass are immunized parenterally twice at seven-day intervals with 0.2 ml of a mixture consisting of Vibrio cholerae O1 El Tor 18950 - 5 µg and Vibrio cholerae O139 17786 - 5 µg external membrane vesicles, the efficiency of cholera immunity modeled by vesicles shall be considered positive in case no generalized cholera occurred in research animals after infecting them.
EFFECT: invention provides possibility to is to obtain cholera immunity in research animals.
1 cl, 3 tbl, 3 ex
| Title | Year | Author | Number |
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| METHOD FOR OBTAINING AMP T PROTEIN FOR ANTI-CHOLERA IMMUNITY MODELLING IN EXPERIMENTAL ANIMALS | 2017 |
|
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| METHOD TO ASSESS BIOLOGICAL ACTIVITY OF LACTOBACILLI AND BIFIDUS BACTERIAL RELATIVE TO CHOLERAIC VIBRIOS IN VITRO | 2012 |
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|
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|
RU2313577C2 |
| METHOD FOR INTRASPECIES DIFFERENTIATION OF Vibrio cholerae O139 | 2004 |
|
RU2268942C1 |
| AVIRULENT STRAIN OF Vibrio cholerae KM 262 BACTERIA OF SEROVAR OGAWA OF BIOVAR ELTOR - PRODUCER OF PROTECTIVE O1 ANTIGEN | 2010 |
|
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| AVIRULENT STRAIN OF MICROORGANISM VIBRIO CHOLERAE KM 169 OF SEROGROUP O139 AS PRODUCER OF CAPSULE ANTIGEN | 2003 |
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| METHOD FOR CHOLERA PREVENTION USING BACTERIOPHAGES | 2021 |
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RU2783000C1 |
| CULTIVATED HYBRID CELL STRAIN OF Mus Musculus L ANIMALS - PRODUCER OF MONOCLONAL ANTIBODIES SPECIFIC TO LPS OF CHOLERA VIBRIO 0139 SEROGROUP | 2010 |
|
RU2425875C1 |
