FIELD: medicine.
SUBSTANCE: invention relates to a new method for obtaining an intermediate compound for the preparation of Carvedilol, known as an alpha- and beta-blocker, which, among other things, produces a pronounced vasodilating effect that reduces afterload on the heart, namely, to a method for obtaining 2-[2-(2-methoxyphenoxy)-ethyl]-isoindole-1,3-dione. The method consists in introducing 1-(2-bromoethoxy)-2-methoxybenzene into interaction with potassium phthalimide in a solution of dimethylformamide at 70-100°C, followed by separation of the target product by adding water. EFFECT: technical result of the proposed method is reduction of the process time in the absence of a catalyst and isolation and purification of the target product without using organic solvents to obtain the target product in the shape of small crystals.
3 cl, 1 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR OBTAINING 1-(2-BROMOETHOXY)-2-METHOXYBENZENE | 2022 |
|
RU2796102C1 |
| 2-([{4-NITROPHENYL}IMINO](PHENYL)METHYL)ISOINDOLINE-1,3-DIONE, METHOD FOR PRODUCTION THEREOF, ANALGESIC AND ANTI-INFLAMMATORY AGENT BASED THEREON | 2022 |
|
RU2789687C1 |
| METHOD OF PRODUCING 3,4-DIHYDROPYRIMIDINO[2,1-A]ISOINDOL-6(2H)-ONE | 2023 |
|
RU2823235C1 |
| METHOD OF PRODUCING 2-HYDROXY-2-CARBOXYALKYLADAMANTANES | 2013 |
|
RU2529190C1 |
| METHOD OF OBTAINING (1S,5R)-6,6-DIMETHYLBICYCLO[3.1.1]HEPTANONE-2 ((-)-NOPINONE) | 2023 |
|
RU2809009C1 |
| DERIVATIVES OF 2-AMINOPYRAZINE-5-CARBOXAMIDE, A METHOD OF THEIR SYNTHESIS AND A DRUG AND A PHARMACEUTICAL COMPOSITION CONTAINING SAID | 1994 |
|
RU2128176C1 |
| IMPROVED PROCESS OF OBTAINING LINEZOLID | 2016 |
|
RU2766082C1 |
| METHOD OF PRODUCING 2,2-ADAMANTYLENE SPIROOXIRANE DERIVATIVES | 2013 |
|
RU2529025C1 |
| METHOD FOR PRODUCTION OF 2-FLUORINE-3-METHYLBUT-2-ENYL AMINE OR ITS HYDROCHLORIDE (VERSIONS) | 2016 |
|
RU2610281C1 |
| METHOD OF PRODUCING 1-ADAMANTYL ISOTHIOCYANATE | 2014 |
|
RU2551682C1 |
