METHOD FOR THE TREATMENT OF PERSISTENT EPITHELIAL CORNEAL DEFECT Russian patent published in 2023 - IPC A61F13/02 A61K35/742 A61P27/02 

FIELD: medicine; ophthalmology.

SUBSTANCE: invention can be used to treat a persistent epithelial corneal defect. The method includes long-term closure of the palpebral fissure and a therapeutic effect on the cornea, the palpebral fissure is closed by applying tapes tightly connecting the upper and lower eyelids for a period until the cornea is completely healed, during this period the palpebral fissure is opened only for examination and installation of drugs, including antiseptic solutions picloxidine hydrochloride 0.05% or antibiotic levofloxacin 0.5% 4 times a day, reparant in the form of dexpanthenol gel 5% or keratoprotector in the form of sodium hyaluronate 0.3% 4 times a day, in combination with instillations of the steroid anti-inflammatory drug dexamethasone at a concentration 0.01–0.1% in descending order: 1st week — 4 times a day, 2nd week — 3 times a day, 3rd week — 2 times a day, 4th week — once daily or without it. Further, in the course of treatment, the patient's adherence to the closure of the palpebral fissure is determined. If the patient is not sufficiently committed to closing the palpebral fissure by applying teips, the patient is injected with botulinum toxin type A Dysport in the amount of 30 U into the muscle that lifts the upper eyelid. With long-term preservation of the epithelial defect of the cornea for a period of more than 55–60 days, an additional therapeutic effect on the cornea is performed by micropuncture of the anterior layers of the corneal stroma.

EFFECT: use of the invention improves the efficiency, availability and safety of treatment of persistent corneal epithelial defect through the use of a stepwise treatment algorithm, including non-invasive and micro-invasive stages, determining the timing of the revision of treatment tactics, the use of taping as a safe method of increasing the hydration of the ocular surface, and also through the use of an available method microinvasive stimulation of corneal epithelium adhesion.

3 cl, 2 ex