FIELD: biotechnology.
SUBSTANCE: disclosed are multispecific binding proteins which bind CD33, NKG2D receptor and CD16, as well as pharmaceutical compositions and therapeutic methods useful for treating cancer.
EFFECT: invention provides improved activation of NK-cells as a result of binding of two activating receptors.
17 cl, 57 dwg, 9 tbl, 13 ex
| Title |
Year |
Author |
Number |
| POLYVALENT BINDING PROTEINS FOR ACTIVATION OF NATURAL KILLER CELLS AND THEIR THERAPEUTIC APPLICATION FOR TREATMENT OF MALIGNANT NEOPLASM |
2018 |
- Chang, Gregory, P.
- Cheung, Ann, F.
- Haney, William
- Grinberg, Asya
|
RU2809125C2 |
| BCMA, NKG2D AND CD16 BINDING PROTEINS |
2018 |
- Chang, Gregory, P.
- Cheung, Ann, F.
- Haney, William
- Lunde, Bradley, M.
- Prinz, Bianka
|
RU2805254C2 |
| PROTEIN BINDING WITH NKG2D, CD16 AND WITH TUMOR-SPECIFIC ANTIGEN |
2018 |
- Chang, Gregory P.
- Cheung, Ann F.
- Haney, William
- Lunde, Bradley M.
- Prinz, Bianka
|
RU2788531C2 |
| PROTEINS BINDING NKG2D, CD16 AND TUMOUR-ASSOCIATED ANTIGEN |
2018 |
- Chang, Gregory, P.
- Cheung, Ann, F.
- Haney, William
- Lunde, Bradley, M.
- Prinz, Bianka
- Grinberg, Asya
|
RU2816716C2 |
| POLYSPECIFIC BINDING PROTEINS TARGETING NKG2D, CD16 AND TROP2 |
2018 |
- Chang, Gregory, P.
- Cheung, Ann, F.
- Gutierrez, Eva
- Haney, William
- Lunde, Bradley, M.
- Prinz, Bianka
|
RU2820629C2 |
| POLY-SPECIFIC BINDING PROTEINS TARGETED TO CAIX, ANO1, MESOTHELIN, TROP2, CEA, AND CLAUDINE-18.2 |
2018 |
- Chang, Gregory, P.
- Cheung, Ann, F.
- Gutierrez, Eva
- Haney, William
- Lunde, Bradley, M.
- Prinz, Bianka
|
RU2792671C2 |
| MODIFIED NON-NATURAL NKG2D LIGANDS WHICH SELECTIVELY DELIVER ATTACHED HETEROLOGOUS MOLECULES TO NON-NATURAL NKG2D RECEPTORS ON CAR CELLS |
2020 |
- Kim, Kaman
- Kileen, Nigel
- Herzig, Eytan
- Greene, Warner
|
RU2823728C2 |
| MODIFIED Α1-Α2 DOMAINS OF NON-NATURAL NKG2D LIGANDS THAT BIND TO NON-NATURAL NKG2D RECEPTORS |
2019 |
- Kim, Kaman C.
- Landgraf, Kyle E.
|
RU2815278C2 |
| IMMUNE CELLS EXPRESSING INVERSE UNIVERSAL CHIMERIC ANTIGEN RECEPTOR, FOR TARGETING VARIOUS MULTIPLE ANTIGENS AND METHOD FOR PRODUCTION AND USE THEREOF FOR TREATING CANCER, INFECTIONS AND AUTOIMMUNE DISEASES |
2019 |
|
RU2824391C2 |
| CRYOPRESERVED CELLS ARE NATURAL KILLERS PRELOADED WITH ANTIBODY CONSTRUCTION |
2019 |
- Rojsh, Uve
- Kokh, Joakhim
- Treder, Martin
- Dulat, Kholger J.
|
RU2819927C2 |
