METHOD FOR OBTAINING FLUOROMETHYL DERIVATIVE Russian patent published in 2023 - IPC C07C231/12 C07C233/33 C07C49/233 C07C49/697 C07C49/813 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a method for producing a fluorinated organic compound, described by the following formula (1):

in which R¹ means phenyl, optionally containing halogen or C_1-6 alkyl, R² means hydrogen or C_1-6 alkyl, R³ means hydrogen, L means alkanediyl, -CONR- or -CO-O-, where R in each occurrence independently is hydrogen or C_1-6 alkyl, R⁴ is hydroxyl or C_1-6 alkyl and R^X is fluoro, provided that when L is -CONR- and R is hydrogen or methyl, R⁴ is not methyl, and that if L is -CO-O-, R⁴ is neither methyl nor propyl, the process comprises an alkene reaction step A of the following formula (2):

with a source of fluorine, which is the source (3a) described by the formula MF_n in which M is H, a metal of group 1 of the Periodic Table of the Elements or a metal of group 2 of the Periodic Table of the Elements and n is 1 or 2, in the presence of an aromatic compound containing hypervalent iodine, or in the presence of an iodine-containing aromatic compound and an oxidant to fluorinate the alkene.

EFFECT: new method for obtaining a fluorinated organic compound which can provide a higher yield and high selectivity in obtaining the target compound.

4 cl, 41 ex