FIELD: biotechnology; medicine; molecular; clinical oncology.
SUBSTANCE: method for diagnosing breast cancer based on a group of long non-coding RNA genes by detecting methylation of marker genes is presented: HAND2-AS1, KCNK15-AS1 and PLUT. Excess methylation thresholds for any two of the three markers (HAND2-AS1, KCNK15-AS1, and PLUT) are significant; while the threshold values for genes are 9.29, 8.76 and 6.01, respectively.
EFFECT: method of invention allows to detect breast cancer with high specificity and sensitivity.
1 cl, 1 dwg, 4 tbl, 3 ex
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