FIELD: biotechnology; obtaining a cell line.
SUBSTANCE: obtained cell line of human skin melanoma mel-Alx-LP can be used as a model system for studying the processes of carcinogenesis and metastasis in vitro, searching for new potential targets in the therapy of skin melanoma, as well as testing antitumor drugs and new therapeutic approaches, it is stored in a specialized collection of cultures cells of the Center for Collective Use “Collection of Vertebrate Cell Cultures” of the Institute of Cytology of the Russian Academy of Sciences under the number “РККК(П) 812Д”.
EFFECT: mel-Alx-LP cell line has stable cultural, morphological, and molecular characteristics and can be used as a positive control in immunohistochemical and immunocytochemical analyzes for the detection of skin melanoma markers; it is characterized by stable expression of the following melanocytic markers: SOX10, MITF.
1 cl, 1 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF INDUCING APOPTOTIC DEATH OF SKIN MELANOMA CELLS | 2011 |
|
RU2455993C1 |
| APPLICATION OF HUMAN SKIN MELANOMA CELL LINE 388mel | 2018 |
|
RU2675541C1 |
| APPLICATION OF HUMAN SKIN MELANOMA CELL LINE mel Cher AS POSITIVE MODEL OF VASCULOGENIC MIMICRY | 2009 |
|
RU2404243C1 |
| SUBDERMAL XENOGRAFTS OF CELL LINE OF AMELANOTIC HUMAN SKIN MELANOMA MEL RAC WITH MUTATION NRAS FOR PRECLINICAL STUDY OF ANTINEOPLASTIC TARGETED AGENTS | 2016 |
|
RU2651939C2 |
| APPLICATION OF CELL LINE OF 369 ADMEL HUMAN SKIN MELANOMA | 2017 |
|
RU2642265C1 |
| CELL PRODUCT FOR LOADING AND ACTIVATION OF HUMAN DENDRITE CELLS | 2019 |
|
RU2714208C1 |
| METHOD OF PRODUCTION OF SUBDERMAL XENOGRAFTS OF CELL LINE OF PEOPLE SKIN MELANOMA mel Cher WITH MUTATION V600E BRAF FOR PRECLINICAL STUDY OF ANTINEOPLASTIC TARGETED AGENTS | 2014 |
|
RU2572569C1 |
| HUMAN MELANOMA CELLULAR LINE mel Kor USED IN PREPARING ANTITUMOR VACCINE | 2005 |
|
RU2287578C1 |
| HUMAN MELANOMA CELLULAR LINE mel IL USED IN PREPARING ANTITUMOR VACCINE | 2005 |
|
RU2287577C1 |
| HUMAN MELANOMA CELLULAR LINE mel P USED IN PREPARING ANTITUMOR VACCINE | 2005 |
|
RU2287575C1 |
