FIELD: bioengineering.
SUBSTANCE: method of production of subdermal xenografts of cell line of people skin melanoma mel Cher with mutation V600E BRAF for preclinical study of antineoplastic targeted agents includes acclimation of the cell line of people skin melanoma mel Cher to rise of Balb/c nude at immunodeficient mice by means of multiple passaging of up to nine subcultures of suspensions of tumour cells (50-60 mg per mouse) with stable rise kinetics, and testing for presence of the mutation V600E BRAF. The subdermal xenografts of cell line of people skin melanoma mel Cher with mutation V600E BRAF for preclinical study of antineoplastic targeted agents are produced.
EFFECT: higher compositions use efficiency.
3 dwg, 4 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| SUBDERMAL XENOGRAFTS OF CELL LINE OF AMELANOTIC HUMAN SKIN MELANOMA MEL RAC WITH MUTATION NRAS FOR PRECLINICAL STUDY OF ANTINEOPLASTIC TARGETED AGENTS | 2016 |
|
RU2651939C2 |
| METHOD FOR TREATMENT OF SW620 HUMAN COLON CANCER IN EXPERIMENT | 2017 |
|
RU2665168C1 |
| METHOD FOR OBTAINING AN ORTHOTOPIC PDX MODEL OF HUMAN BRAIN GLIOBLASTOMA ON IMMUNODEFICIENT MICE FOR PRECLINICAL STUDY OF ANTITUMOR EFFECTS OF CYTOSTATIC DRUGS | 2021 |
|
RU2761892C1 |
| BRAF KINASE INHIBITOR N-(3-(5-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-3-CARBONIL)-2,4-DIFLUOROPHENYL)PROPANE-1-SULFONAMIDE | 2018 |
|
RU2687107C1 |
| APPLICATION OF HUMAN SKIN MELANOMA CELL LINE mel Cher AS POSITIVE MODEL OF VASCULOGENIC MIMICRY | 2009 |
|
RU2404243C1 |
| N-(3-(5-(4-CHLOROPHENYL)-1N-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONYL)-2,4-DIFLUOROPHENYL)PROPANE-1-SULPHONAMIDE CRYSTALLINE FORM, ACTIVE COMPONENT, PHARMACEUTICAL COMPOSITION AND MEDICINE | 2018 |
|
RU2678455C1 |
| METHOD FOR EVALUATING EFFICACY OF RADIOPROTECTIVE DRUGS USING HUMANISED MICE | 2023 |
|
RU2817986C1 |
| METHOD FOR OBTAINING AN ORTHOTOPIC PDX MODEL OF SQUAMOUS CELL CARCINOMA OF THE HUMAN ESOPHAGUS FOR THE STUDY OF RADIATION THERAPY IN AN EXPERIMENT | 2021 |
|
RU2760084C1 |
| COMBINED THERAPY PAC-1 | 2016 |
|
RU2720509C2 |
| CELL LINE OF HUMAN MELANOMA mel Cher, USED FOR OBTAINING ANTI-TUMOR VACCINES | 2008 |
|
RU2364624C1 |
