1,3,4-OXADIAZOLE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITOR AND PHARMACEUTICAL COMPOSITION CONTAINING THEM Russian patent published in 2022 - IPC C07D413/04 C07D413/14 C07D417/14 A61K31/443 A61K31/4439 A61P25/00 A61P27/02 A61P3/00 A61P31/00 

FIELD: pharmaceutics.

SUBSTANCE: present invention relates to 1,3,4-oxadiazole derivatives described by formula I, their optical isomers or their pharmaceutically acceptable salts. In the formula I: X, Y and Z all mean CR₃ independently; L means -(C₁-C₆ alkylene)-, -(C₂-C₆ alkenylene)-, -(C=O)-(C₁-C₄ alkylene)-, -(C=O)O-(C₁-C₄ alkylene)-,-(C=O)NH-(C₁-C₄ alkylene)-, -O(C=O)-(C₁-C₄ alkylene)- or an ordinary bond, where at least one H group - (C₁-C₆ alkylene)-, -(C₂-C₆ alkenylene)-, -(C=O)-(C₁-C₄ alkylene)-, -(C=O)O-(C₁-C₄ alkylene)-, -(C=O)NH-(C₁-C₄ alkylene)- and -O(C=O)-(C₁-C₄ alkylene)- can be substituted with phenyl; R₁ means hydrogen, -C₁-C₆ alkyl, -C₂-C₆ alkenyl, -C₃-C₈ cycloalkyl, hetero cycloalkyl, benzyl, aryl, heteroaryl or -NR₄R₅, where at least one H of aryl or heteroaryl can be replaced by a group of -C₁-C₆ alkyl, -C₂-C₆ alkenyl, -C₁-C₆ haloalkyl, -C₁-C₆ alkoxy group, halogen, nitro group, -CF₂H, -CF₃ or -S(=O)₂-R₉; R₂ means -CF₂H or -CF₃; R₃ means hydrogen; R₄ and R₅ all independently mean H or -C₁-C₆ alkyl; and R₉ means H or -C₁-C₆ alkyl. A pharmaceutical composition and a method for inhibiting histone deacetylase 6 (HDAC6) have also been proposed.

EFFECT: proposed compounds have inhibitory activity with respect to histone deacetylase 6 and are effective for the prevention or treatment of HDAC6-related diseases.

[Formula I ]

9 cl, 2 tbl, 59 ex