FIELD: pharmaceutics.
SUBSTANCE: present invention relates to 1,3,4-oxadiazole derivatives described by formula I, their optical isomers or their pharmaceutically acceptable salts. In the formula I: X, Y and Z all mean CR3 independently; L means -(C1-C6 alkylene)-, -(C2-C6 alkenylene)-, -(C=O)-(C1-C4 alkylene)-, -(C=O)O-(C1-C4 alkylene)-,-(C=O)NH-(C1-C4 alkylene)-, -O(C=O)-(C1-C4 alkylene)- or an ordinary bond, where at least one H group - (C1-C6 alkylene)-, -(C2-C6 alkenylene)-, -(C=O)-(C1-C4 alkylene)-, -(C=O)O-(C1-C4 alkylene)-, -(C=O)NH-(C1-C4 alkylene)- and -O(C=O)-(C1-C4 alkylene)- can be substituted with phenyl; R1 means hydrogen, -C1-C6 alkyl, -C2-C6 alkenyl, -C3-C8 cycloalkyl, hetero cycloalkyl, benzyl, aryl, heteroaryl or -NR4R5, where at least one H of aryl or heteroaryl can be replaced by a group of -C1-C6 alkyl, -C2-C6 alkenyl, -C1-C6 haloalkyl, -C1-C6 alkoxy group, halogen, nitro group, -CF2H, -CF3 or -S(=O)2-R9; R2 means -CF2H or -CF3; R3 means hydrogen; R4 and R5 all independently mean H or -C1-C6 alkyl; and R9 means H or -C1-C6 alkyl. A pharmaceutical composition and a method for inhibiting histone deacetylase 6 (HDAC6) have also been proposed.
EFFECT: proposed compounds have inhibitory activity with respect to histone deacetylase 6 and are effective for the prevention or treatment of HDAC6-related diseases.
[Formula I ]
9 cl, 2 tbl, 59 ex
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