DERIVATIVES OF QUINOLINE-PYRROLIDINE-2-ONE AND APPLICATION THEREOF Russian patent published in 2022 - IPC C07D471/20 C07D491/20 A61K31/4745 A61K31/4747 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely to a derivative of quinoline pyrrolidine-2-one by the formula (I), an isomer or a pharmacologically acceptable salt thereof, where E is selected from -N(R₅)-, -O- and -C(R₆)(R₇)-; R₁ is selected from a C_1-3 alkyl and a C_3-6 cycloalkyl; R ₂ constitutes H; R ₃ is selected from H, F, Cl; R₄ is selected from a C_1-6 alkyl and N(R_c)(R_d); R₅ is selected from H, a C_1-6 alkyl, a C_3-6 cycloalkyl, a C_1-6 alkyl-C=O-, a C_1-6 alkyl-O-C=O- and a C_3-6 cycloalkyl-C=O-, wherein said C_1-6 alkyl is optionally substituted with 1, 2 or 3 R_e; each of R₆ and R₇ is independently selected from H, F, OH, a C_1-6 alkyl and a C_1-6 alkoxy; L₁ is selected from a single bond and -(CH₂)_m-O-; m is selected from 1, 2 and 3; ring B constitutes a 5-6-membered heteroaryl; each of R_c and R_d is independently selected from a C_1-3 alkyl and a C_3-6 cycloalkyl; or R_c and R_d jointly with the N atom whereto they are attached form a 5-6-membered heterocycloalkyl, optionally substituted with 1 R; R_e constitutes F; R constitutes F; and each of said 5-6-membered heteroaryl and 5-6-membered heterocycloalkyl independently comprises 1 or 2 heteroatoms independently selected from -NH- and N. The invention also relates to a specific derivative of quinoline pyrrolidine-2-one and an application thereof for producing a medicinal product capable of inhibiting ATM kinase.

EFFECT: production of new heterocyclic compounds useful in treatment of diseases associated with inhibition of ATM kinase.

19 cl, 2 dwg, 5 tbl, 38 ex