BIORELEVANT MEDIUM OF FASTED CATTLE INTESTINE Russian patent published in 2023 - IPC A61K35/413 A61K31/685 A61K33/08 A61K33/14 A61K33/42 

FIELD: analytical chemistry.

SUBSTANCE: invention can be used in medical, veterinary and other biological research to assess the bioavailability of drugs, simulate the processes of their dissolution and absorption, as well as to study the features of cattle digestion processes. Biorelevant medium of fasted cattle intestine containing lecithin, potassium dihydrogen phosphate, potassium chloride, sodium hydroxide and demineralized water, characterized by its additionally containing cattle bile in the following ratio of components per 1 liter of demineralized water: 0.75 μmol of lecithin; 3.9 g of potassium dihydrogen phosphate; 7.7 g of potassium chloride; sodium hydroxide to provide a pH of 7.5; 2 g of cattle bile; 1 l of demineralized water.

EFFECT: biorelevant bovine intestinal medium described above imitates fasted cattle intestinal juice in vitro with high fidelity.

1 cl, 2 tbl