METHOD OF TREATMENT AND/OR PREVENTION OF ASTHMA, ASTHMA AGGRESSION, ALLERGIC ASTHMATIC DISORDERS AND/OR RESPIRATORY DISORDERS ASSOCIATED WITH MICROBIOTA Russian patent published in 2023 - IPC A61K35/74 C12N1/20 A61P11/00 A61P11/02 A61P11/04 A61P11/06 A61P17/00 

FIELD: medicine.

SUBSTANCE: invention relates to a method of the treatment or prevention of asthma, exacerbation of asthma, allergic asthmatic disorders or symptoms associated with bronchial obstruction. A method of treating or preventing asthma, exacerbation of asthma, allergic asthmatic disorders, or symptoms associated with bronchial obstruction in a subject in need thereof, comprising administering a therapeutically effective amount of a bacterial extract derived from gram-positive or gram-negative bacterial species selected from Moraxella catarrhalis, Haemophilus influenzae, Klebsiella pneumoniae, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes and/or Streptococcus sanguinis, wherein the said bacterial extract can be obtained by alkaline lysis, and wherein the said bacterial extract is administered intranasally or intratracheally.

EFFECT: above invention provides an effective and reliable approach to the prevention of allergic inflammation in the respiratory tract, while restoring a healthy microbiome of a host suffering from asthma and allergy-induced exacerbations associated with microbiota imbalance.

6 cl, 14 dwg, 1 tbl, 13 ex