METHOD OF DIAGNOSING TREATMENT RESPONSE IN PATIENTS WITH COLORECTAL CANCER LIVER METASTASES Russian patent published in 2023 - IPC G01N33/53 A61B5/00 

FIELD: medicine, oncology.

SUBSTANCE: invention can be used to evaluate the effectiveness of treatment in patients with colorectal cancer with liver metastases. The method is carried out by determining blood levels of oncomarkers of cancer-embryonic antigen (CEA) and complementary marker CA 19-9 before treatment, the results of which are summarized and then the sum of these indicators is determined after ongoing chemotherapy treatment. After that, a comparative assessment is made of the obtained sum of oncomarker concentration levels after treatment with the sum of oncomarker concentration levels obtained before the treatment. With a decrease in the sum of oncomarker concentration levels by more than 30% relative to the sum of oncomarker concentration levels before chemotherapy, it is assessed as a partial response to this treatment, that is, a decrease in the sum of the diameters of targeted metastatic foci and the appearance of new metastatic foci by more than 30% relative to the indicators before starting chemotherapy treatment. With an increase in the sum of indicators of the concentration levels of oncomarkers by more than 20% relative to the indicators of the sum of the levels of concentrations of oncomarkers before the ongoing chemotherapy treatment, it is evaluated as progression to this treatment, that is, an increase in the size of targeted metastatic foci and the appearance of new metastatic foci by 20% relative to the indicators before the start of the ongoing chemotherapeutic treatment. With a decrease in the sum of indicators of levels of concentration of oncomarkers by less than 30% or an increase by not more than 20% relative to the indicators of the sum of levels of concentrations of oncomarkers before chemotherapy treatment is evaluated as stabilization for this treatment, that is, a decrease in tumor formations by less than 30% or an increase not by more than 20% and the appearance of new lesions relative to the indicators before the start of the chemotherapy treatment. The invention provides an extension of the arsenal of technical means for evaluating the effectiveness of ongoing chemotherapy treatment in patients with colorectal cancer with liver metastases with high reliability at an early stage of chemotherapy treatment.

EFFECT: method allows to improve the overall survival of patients due to the early diagnosis of the progression of the tumor process.

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